It was administered iv and orally in single doses of 80 mg fenspiride hydrochloride according to a randomised crossover pattern. In a dream i had ten years in the future, my pet snail told me about his experience using a combination of phenethylamine hcl pea capsules and hordenine capsules. Determination and validation of duloxetine hydrochloride in. The effect of fenspiride on neurallymediated mucus secretion was investigated in vitro in electricallystimulated ferret trachea, using 35 so 4 as a mucus marker. The urgency to satisfy pharmaceutical regulatory requirements, including drug quality risk management, prompted the application of risk assessment methodology during the pharmaceutical development pd stage of an actual drug production process to be studied. It is approved for use in russia for the treatment of acute and chronic inflammatory diseases of ent organs and the respiratory tract like rhinopharyngitis, laryngitis, tracheobronchitis, otitis and sinusitis, as well as for maintenance treatment of asthma. Single dose pharmacokinetics of fenspiride hydrochloride.
An antiinflammatory and bronchodilator agent fenspiride hydrochloride is an antiinflammatory and bronchodilator agent with low cyclooxygenase cox inhibitory activity. A list of us medications equivalent to fenspiride hydrochloride is available on the website. Fenethylline hydrochloride american chemical society. A simple, selective, accurate high performance liquid chromatographic hplc method was developed and validated for the analysis of fenspiride hydrochloride in bulk and tablet dosage forms. Ep1064935b2 ep00401825a ep00401825a ep1064935b2 ep 1064935 b2 ep1064935 b2 ep 1064935b2 ep 00401825 a ep00401825 a ep 00401825a ep 00401825 a ep00401825 a ep 00401825a ep 1064935 b2 ep1064935 b2 ep 1064935b2 authority ep european patent office prior art keywords. The pharmacotherapeutic classification is antitussives. Montes b1, catalan m, roces a, jeanniot jp, honorato jm. Each 5 ml contains 10 mg fenspiride hydrochloride excipients. Captagon was first synthesized in 1961 for the treatment of hyperactivity, depression and narcolepsy.
We offer as per requirements of rnd development quantities or commercials, buy high quality source with supportive technical package. Fenspiride hydrochloride is an antiinflammatory and bronchodilator agent with low cyclooxygenase cox inhibitory activity. Study to investigate the antiinflammatory effect of. Detection of fenspiride and identification of in vivo. Api produced following this new route meets the quality requirement nlt 99. Fenspiride hydrochloride is a medicine available in a number of countries worldwide. The indian pharmacopoeia 2007 has been prepared in accordance with the principles and designed plan decided by the scientific body of the indian pharmacopoeia commission and completed with untiring efforts made by commission members and its secretariat over almost two years. Fenspiride hydrochloride 5053087 tci chemicals india. Fenspiride is an oxazolidinone spiro compound used as a drug in the treatment of certain respiratory diseases. Fenspiride hydrochloride has a complex antiinflammatory effect on the mucous membrane of respiratory tract rt in acute respiratory infection ari.
Hordenine is a natural stimulant derived from the bitter orange fruit. Some aspects of quality risk management for the fenspiride hydrochloride 0. Different solvents methanol, acetonitrile, dichloromethane. Following enzymatic deconjugation, fenspiride and its phase i metabolites were isolated from postadministration biofluids using bonded copolymeric. The present invention relates to a new solid pharmaceutical composition, with controlled release, obtained by hot thermoforming of a mixture based on polymers belonging to the family of polymethacrylates, and of active principle s medicinal product s. Toronto research chemicals 20 martin ross avenue north york, on canada, m3j 2k8 international. Fenspiride hydrochloride cas 5053087 scbt santa cruz. Panacur, safeguard antiparasitic agent systemic drug sign in to continue reading this drug monograph.
Following iv administration, the plasma clearance of fenspiride was about 184 mlmin. The incorporation tendency of fenethylline fnt and its metabolite into rat hair and the discrimination between fnt use and amphetamine ap use by hair analysis using gas chromatographymass spectrometry with selected ion monitoring are described. Inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level by its antimuscarinic action. Fenspiride is an antagonist of histamine h 1 receptors and a nonsteroidal antiinflammatory drug nsaid. A highperformance liquid chromatographic hplc method is described for the determination of duloxetine hydrochloride in capsules. Studying the effect of different nbdcl reagent concentrations on the produced fluorescence intensity revealed that highest fluorescence intensity was over the concentration of nbdcl reagent in the final solution between 0. Fenspiride is a nonsteroidal antiinflammatory agent which has a variety of actions, including inhibition of neurogenic bronchoconstriction. The great thing about hordenine is that, like pea, it is also broken down by the maob enzyme. Cas registry number chemical abstracts service 0005053065. It is supplied as a lightblue, capsuleshaped tablet for oral administration.
Emas safety committee has recommended that the marketing authorisations for fenspiride medicines be revoked, so the medicines can no longer be marketed in the eu. Pdf development and validation of rphplcpda method for. After the intraperitoneal administrations of fnt to pigmented hairy rats 5 mgkgday, 10 days, n 3, concentrations of fnt and its metabolite. Fenethylline is a combination of the drugs amphetamine and theophylline. Cas 5053087, fenspiride hydrochloride manufacturer. Each tablet contains fenspiride hydrochloride 40mg 4 160mg mm 200610 0. A bioanalytical method designed for the bioequivalence of fenspiride containing pharmaceutical formulations was based on a sample preparation procedure involving extraction of the target analyte and the internal standard trimetazidine from alkalinized plasma samples in 1octanol. Click on any entry to see the full record, or try a new searchlick on any entry to see the full record, or try a new search. Captagon is the trademark name for the synthetic stimulant fenethylline hydrochloride, which is a central nervous system stimulant with euphoric and analgesic properties. Subscribe to plumbs veterinary drugs to create and save personal notes for every drug you use.
This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Acting on the metabolism of arachidonic acid, fenspiride reduces the formation of prostaglandins and leukotrienes, being an antagonist of h1histamine receptors and. Nitroaldol approach for commercial manufacturing of. Some aspects of quality risk management for the fenspiride. Where medical attention is not immediately available or where the patient is more than 15 minutes from a hospital or unless instructed. List of ip reference substances available at ipc, ghaziabad. Nitroaldol condensation is the key reaction in the developed process.
Fenspiride inn, brand names eurespal, pneumorel and others is an oxazolidinone spiro compound used as a drug in the treatment of certain respiratory diseases. Extreme high moderate low section 1 chemical product and company identification product name fenspiride hydrochloride statement of hazardous nature considered a hazardous substance according to osha 29 cfr 1910. In russia it was approved for the treatment of acute and chronic inflammatory diseases of ent organs ear, nose, throat and the respiratory tract like rhinopharyngitis. Apr 11, 2019 lotronex alosetron hydrochloride tablets are supplied for oral administration as 0. Largevolume injection of sample diluents not miscible. Fenspiride hydrochloride sc207684 hazard alert code key.
It has been used for the treatment of certain respiratory diseases. Get instant digital access to plumbs veterinary drugs with new drugs and updates added monthly. Withdrawal of marketing authorisations for fenspiride. Welcome to contact us for further details including current dmf status for the product.
A list of us medications equivalent to fenspiride hydrochloride is available on the drugs. Buy high quality fenspiride hydrochloride 5053087 from toronto research chemicals inc. An efficient, short manufacturing process for fenspiride hydrochloride is reported. Request pdf new approach for determination of the degradation products of fenspiride hydrochloride found in oral liquid formulations fenspiride hydrochloride fns is used in treating chronic. S fenspiride 029437 0523 178 fenspiride serotonine, histamine. Fenspiride potentiates the airway relaxant effects of isoproterenol item no. A volume of 75 l from the octanol layer was directly.
Hordenine is an alkaloid extracted from specific type of cactus and in the class of pearelated chemicals. Aerosolized fenspiride 1 mgml reverses bronchoconstriction induced by capsaicin and, when used at aerosolized concentrations ranging from 110 mgml, reduces. Education software downloads hyperchem by hypercube, inc. Narcotic drug chemical name description na 001 25333771 acetorphine 3oacetyltetrahydro7. Phenylethylamine pea and hordenine nootropics hacks. Studies related to the in vivo biotransformation and urinary excretion of fenspiride hydrochloride in the horse are described. The indian pharmacopoeia 2007 is presented on the user friendly format. Fenoterol hydrobromide is also given orally to children for the relief of bronchospasm in the following doses. Hcl is a whitish watersoluble microcrystalline solid. The merck index online search returned the following results, ranked in order of relevance. Effect of fenspiride, a nonsteroidal antiinflammatory. Largevolume injection of sample diluents not miscible with.
In russia it was approved for the treatment of acute and chronic inflammatory diseases of ent organs ear, nose, throat and the. Fenspiride hydrochloride cas 5053087 cayman chemical. Sotalol hydrochloride usp is an antiarrhythmic drug with class ii betaadrenoreceptor blocking and class iii cardiac action potential duration prolongation properties. For batch specific data refer to the certificate of analysis. It is marketed in european countries in tablet, syrup or injectable solution forms in proprietary formulations decaspir, espiran, fenspir, pneumorel, respiride, tegencia and viarespan for human use. Atc anatomical therapeutic chemical classification r03bx01,r03dx03. Feb 05, 2002 studies related to the in vivo biotransformation and urinary excretion of fenspiride hydrochloride in the horse are described. It was formerly used to treat conditions such as adhd, narcolepsy, and depression. Data sources include ibm watson micromedex updated 10 apr 2020, cerner multum updated 6 apr 2020, wolters kluwer updated. Sotalol hydrochloride usp is a white, crystalline solid with a molecular weight of 308. Lotronex alosetron hydrochloride tablets are supplied for oral administration as 0. It is promoted by terrorist groups such as the islamic state to enhance what they consider to be desirable characteristicsaggressiveness, alertness, and fearlessnessin their recruits. Fexofenadine hydrochloride iprs7115 iprs0311 052016 200 mg 221.
He told me that he was skeptical about the effects of legal substances but was hoping they. The method was based on precolumn derivatization with 4chloro7nitrobenzo2oxa1,3diazole using the fluorimetric detection technique. Ep1064935a1 solid thermoformable controlledrelease. Fenspiride hydrochloride oxofen 2 mgml syrup for oral use active substance. Fenethylline reemerged this year because of its widespread abuse by middle eastern young adults. Fenspiride hydrochloride 82phenylethyl1oxa3,8diazaspiro4,5decan2one. Jigs chemical is global manufacturer, supplier of fenspiride hydrochloride cas no. Ep1064935b2 compositions pharmaceutiques solides a. Fenspirided5 hydrochloride is a labelled fenspiride. Improved routes to key building blocks are demonstrated by expedient multikilogram production. Effect of fenspiride, a nonsteroidal antiinflammatory agent.
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